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Webinars & Online Seminars

An online learning resource

DiscoverX offers a number of upcoming and previously recorded webinars, recorded online meetings and presentations with our scientists that cover a variety of relevant topics, tools and data analysis techniques.

 
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SAFETYscan: オフターゲット効果を機能アッセイで同定,GPCR・...
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Event Date ▼ Event Name PDF Link Webinar Link
May 19, 2017 SAFETYscan: オフターゲット効果を機能アッセイで同定,GPCR・チャネル・キナーゼ等を一気にスクリーニング - 60 min.

What will be covered?

  • 全てのヒトのターゲットで安全性を確認
  • 通常の結合データを上回る機能データ
  • アッセイ開発のコストと時間を削減
  •  
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April 19, 2017 Webinar: Combining Target-Based and Phenotypic Discovery Assays for Drug Repurposing - 40 min.

What will be covered?

  • Using phenotypic profiling to characterize clinically successful drugs for a given indication
  • Combining target-based and phenotypic data to prioritize drugs for repurposing
  • Understanding how multi-targeted kinases can be pivoted towards new indications
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April 5, 2017 Webinar: From Chemistry to Clinic: Discovery of Biased Apelin Receptor Agonists and Action in the Cardiovascular System - 55 min.

What will be covered?

  • Role of GPCRs in human cardiovascular system
  • Strategies for exploiting orphan GPCRs recently paired with endogenous ligands illustrated by Apelin and Elabela/Toddler
  • Identifying biased agonists using pharmacologically-relevant functional cell based assays
  • Validating assays and minimizing inter-assay variation
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March 29, 2017 Webinar: Creating Cellular Target Engagement Assays for Diverse Kinases Using InCELL Pulse™ - 30 min.

What will be covered?

  • Overview of compound-target engagement and InCELL Pulse platform
  • Kinase drug discovery importance
  • Tools and workflow needed to create your own target engagement assay
  • Validation data showing several examples of diverse kinases
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March 10, 2017 免疫チェックポイント阻害剤の評価に適切なセルベースアッセイ系のご紹介 - 60 min.

What will be covered?

  • 抗腫瘍免疫応答が増強に活用される免疫チェックポイント阻害剤の評価系
  • PD-1, PD-L1, PD-L2, TWEAK, CD40, OX40, VISTA などの実施例
  • 放射性同位体を使用しないADCC(抗体依存性細胞傷害)の評価系
  •  
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March 9, 2017 Webinar: Mu Opioid Receptor Splicing and Signaling: Another Dimension of GPCR Function - 55 min.

What will be covered?

  • Overview of the mu opioid receptor signaling
  • GPCR splicing, using OPRM1 as an example
  • Region and cell specific splicing
  • Functional consequences of 5’ splicing
  • Functional consequences of 3’ splicing
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February 1, 2017 Webinar: Unlocking GPCRs for Oncology - 35 min.

What will be covered?

  • Opportunities and challenges for targeting GPCRs in oncology
  • Examples of GPCR-targeting investigational therapies for oncology
  • Imipridones, selective GPCR-targeting small molecules, that are in preclinical and clinical development for oncology
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December 7, 2016 Webinar: The Interplay of Kinase Broad Profiling and Phenotypic Screening - 60 min.

What will be covered?

  • Learn about the significance of kinase broad profiling and phenotypic screening on early kinase drug discovery
  • Learn how to design a kinase inhibitor broad profiling project and how the chemo-bioinformatic analysis can impact target deconvolution after phenotypic screening
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November 30, 2016 Webinar: Create Your Own InCELL Pulse™ Cellular Compound-Target Engagement Assay - 60 min.

What will be covered?

  • Overview of compound-target engagement
  • Tools needed to create your own target engagement assay
  • Experimental design and workflow
  • Applications of InCELL Pulse assays
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November 9, 2016 Webinar: Duplexed Screening of GPCRs to Measure Calcium and β-Arrestin - 60 min.

What will be covered?

  • Screening approaches for GPCR drug discovery
  • Creating a duplexed assay to monitor calcium and β-arrestin in a single well
  • Determine potential bias for various drugs and define potency ranking
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October 26, 2016 Webinar: Target to Phenotype: Tools to Accelerate Your Immuno-Oncology Drug Pipeline - 60 min.

What will be covered?

  • Challenges in immuno-oncology drug development
  • Tools to expedite and simplify any immuno-oncology drug development pipeline
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September 30, 2016 Webinar: Immuno-Oncology Drug Development: Profiling Immunomodulatory Biologics and Compounds in Human Primary Cell-Based Oncology Models - 60 min.

What will be covered?

  • Overview of the BioMAP® immuno-oncology/oncology systems
  • Information BioMAP iOnc studies provide
  • Host stromal/vascular - tumor microenvironment biology
  • Case studies of profiling Ab therapies (anti-PD-1, anti-CTLA-4, etc.) and preclinical compounds
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September 9, 2016 DiscoverX:常に進化を続けている創薬・新薬開発市場への支援 - 60 min.

What will be covered?

  • 2016の創薬市場:「スマート」になった現在の薬剤
  • チェックポイント阻害剤の評価系・インターロイキン受容体・GPCR等
  • キナーゼ阻害剤・エピジェネティック阻害剤・PPI創薬のスクリーニング
  • 候補薬剤の表現型プロファイリング
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August 10, 2016 Webinar: New Tricks for Old Drugs: An Unbiased Phenotypic Approach to Drug Repurposing - 40 min.

What will be covered?

  • Overview of the BioMAP Diversity PLUS phenotypic screening platform's modeling of broad human tissue and disease biology
  • Details of how Diversity PLUS profiling guides new indications for marketed drugs and pre-clinical candidates
  • Examples highlighting how this technology is used to support repositioning of approved drugs for alternate indications
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July 27, 2016 Webinar: Understand Safety and Selectivity of Drug Candidates Before Expensive Animal Studies - 60 min.

What will be covered?

  • How PathHunter® GPCR Screening and Profiling Services can be used to triage hits, rank order compounds, and develop novel biased ligands
  • Tools to understand the mechanism of action of your drugs and their mode of action
  • How a case study of clinically approved drugs in our broad range of GPCR assays can be used to predict the selectivity and safety of your drug candidates
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July 20, 2016 Webinar: Introduction to KINOMEscan: Broad Applications to Drive Drug Discovery - 60 min.

What will be covered?

  • Overview of the KINOMEscan assay technology
  • Application of the KINOMEscan platform for selectivity and potency optimization
  • Development of chemical probes for understudied kinases
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June 29, 2016 Webinar: Building Relevant Cell-Based Assays for Co-Stimulatory and Co-Inhibitory Checkpoint Receptors - 60 min.

What will be covered?

  • Novel cell-based assays for checkpoint signaling receptors
  • Functional assays for biologics and small molecule screening
  • Applications for QC lot release testing of biologics
  • Assays for CD137, CTLA-4, TIGIT, PD-1, OX-40, CD40, TWEAK, TIM3, and VISTA
  • Custom assay development for novel checkpoint targets
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June 17, 2016 データまで二週間:キナーゼ・ブロモドメイン・アポトーシス阻害剤を評価 - 60 min.

What will be covered?

  • KINOMEscanアッセイ原理の詳細:結合系と機能系を比較
  • 新規キナーゼ標的:CDK10, CDK12, CDK20, MLKL and MLKL (full length), IRAK2 等
  • 40種類ものブロモドメインに対する阻害剤を評価
  • アポトーシス阻害剤の同定:BCL2scan
  • scanMAX報告書から得られる、裏データ・裏情報のご紹介
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June 15, 2016 Webinar: Make Your Own Cell-Based Assays to Study β-Arrestin Recruitment - 30 min.

What will be covered?

  • Overview of β-arrestin biology
  • Tools needed to create your own β-arrestin cell lines and assays
  • Experimental design and workflows
  • Applications of β-arrestin cell-based assays for GPCRs
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June 1, 2016 Webinar: Specifically Measure Target Cell Death for ADCC, ADCP, BiTe-like Bispecifics, and CAR-T - 45 min.

What will be covered?

  • Simple cell-based assays to measure target cell cytotoxicity in a co-culture
  • Assays for ADCC, ADCP, bi-specific antibody mediated T-cell redirection, and adoptive T-cell therapies such as CAR-T
  • Enabling technology to drive a cancer immunotherapy drug through the discovery and development pipeline
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May 25, 2016 Webinar: A Phenotypic Platform for Characterization of Drug Safety Mechanisms in Human Primary Cell Disease Models - 40 min.

What will be covered?

  • How to maximize knowledge of your compounds using the BioMAP® Diversity PLUS™ panel of human primary cells systems
  • How to understand mechanism classification analysis and toxicity signatures
  • A case study on discovery of a mechanism-based novel signature for skin irritation
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May 19, 2016 Webinar: Ready-to-use Potency Assays for Anti-VEGF Drugs Like Bevacizumab, Ranibizumab & Aflibercept - 60 min.

What will be covered?

  • Creation of cell-based bioassays for potency and stability testing
  • Application, development and validation of assays with drug molecule
  • Case studies on Avastin (bevacizumab), Eylea (aflibercept) and Lucentis (ranibizumab)
  • Qualified assays for > 30 biosimilars
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May 12, 2016 Webinar: Latest Trends in Ligand Bias and Allosteric Modulators – New Opportunities, Insights and Prospects for Cure - 60 min.

What will be covered?

  • Capabilities overview of LeadHunter Discovery Services
  • Identifying, characterizing and quantifying novel biased ligands using LeadHunter Services
  • Multiple pathways including ß-Arrestin and how biased signaling can influence efficacy in vivo
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April 22, 2016 BioMAP表現型プロファイリング:今まで見えなかった試験物質の一面を明瞭に - 60 min.

What will be covered?

  • Tofacitinibの様な抗炎症剤から、食材までの表現型解析例の紹介
  • 臨床試験への架け橋となったデータの実施例
  • Skin Rash・Thrombosis等を明瞭に:BioMAPシステムの応用例
  • パワーアップした試験報告書のご紹介:さらに充実したデータのご提供
  • メカニズム探査によるリード化合物の毒性、薬理、安全性等の同定
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April 20, 2016 Webinar: Identify Compounds that Rescue Disease Relevant Mutant Membrane Proteins - 30 min.

What will be covered?

  • Overview of membrane protein trafficking and protein misfolding diseases
  • Assay technology to simplify monitoring of protein trafficking
  • Screening for pharmacological chaperones
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March 30, 2016 Webinar: Enabling Development of Cancer Immunotherapy Drugs – From Discovery to Combination Strategies - 60 min.

What will be covered?

  • Simple cell-based assays for checkpoint signaling receptors
  • Assays with human primary cells in co-culture recreating the human tumor microenvironment
  • Enabling technologies to move an immune-oncology drug along the discovery and development pipeline
  • Drugs targeting PD-1, PD-L1, PD-L2, TWEAK, CD40, OX40, and VISTA, among others
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March 25, 2016 免疫チェックポイント阻害剤の評価に適切なセルベースアッセイ系のご紹介 - 60 min.

What will be covered?

  • 抗腫瘍免疫応答が増強に活用される免疫チェックポイント阻害剤の評価系
  • PD-1, PD-L1, PD-L2, TWEAK, CD40, OX40, VISTA などの実施例
  • 放射性同位体を使用しないADCC(抗体依存性細胞傷害)の評価系
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March 16, 2016 KINOMEscan Profiling Services Webinar: Efficient Design and Interpretation of KINOMEscan Experiments: A Driver for All Stages of Drug Development - 60 min.

What will be covered?

  • Application of KINOMEscan technology for selectivity and potency optimization of your lead molecules
  • Design scanMAX, KdELECT or scanELECT experiments
  • Improved flexibility of custom panels for hit identification, hit to lead, SAR and lead optimization
  • 20 new kinase assays launched in 2016
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February 17, 2016 Biologics Webinar: Novel, Improved Cell-Based Assays to Enable Immunotherapy Drug Development for Checkpoint Receptors - 60 min.

What will be covered?

  • Novel cell-based assays for checkpoint signaling receptors
  • PD-1, PD-L1, PD-L2, TWEAK, CD40, OX40, and VISTA, among others
  • Functional assays for biologics and small molecule screening
  • Applications for QC lot release testing of biologics
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December 11, 2015 Introduction to BioMAP® Systems: Phenotypic drug profiling in human primary cell systems - 60 min.

What will be covered

  • How BioMAP systems creates a unique profile for your drug
  • Case studies using the screening technology platform
  • Applications for phenotypic drug discovery
  • Services offered for compound profiling
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November 6, 2015 被験化合物によるGi ToxやSkin Rash等を明瞭に:BioMAPシステムの応用例 - 60 min.

eSeminarの課題:

  • Gi Tox、Skin Rash等の応用実施例の紹介
  • リード化合物の選択や臨床標準治療との直接比較
  • メカニズム探査によるリード化合物の毒性、薬理、安全性等の同定
  • 2016年度パネルスケジュール
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October 14, 2015 Introduction to KINOMEscan® - Kinase Screening and Profiling Services - 35 min.

What will be covered

  • Overview of the KINOMEscan technology
  • Analysis of the KINOMEscan study report and included data information
  • Application of the KINOMEscan platform for Selectivity and Potency optimization
  • Data visualization tool: TREEspot
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September 24, 2015 Ligand Bias Simplified - A Novel Pharmacologic Toolbox - 30 min.

What will be covered

  • Capabilities overview of LeadHunter Discovery Services
  • How LeadHunter can be used to identify, characterize and quantify novel biased ligands
  • Discover how multiple pathways including ß-Arrestin can influence efficacy in vivo
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September 4, 2015 新技術のご紹介:セルベースアッセイ系、表現型プロファイリング試験サービス - 60 min.

eSeminarの課題:

  • ADCC活性(Antibody-Dependent-Cellular-Cytotoxicity:抗体依存性細胞傷害)の評価系
  • インターロイキン受容体のセルベースアッセイ
  • BioMAP: MicroArray、FACS、下流タンパク質のリン酸化状態の追加サービス
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August 26, 2015 Application of Enzyme Fragment Complementation Technology in Cell-based Assay for Drug Development - 60 min.

What will be covered

  • Basics of Enzyme Fragment Complementation (EFC)
  • Application of EFC in protein-protein interaction, protein movement and protein quantification study in a cell-based setting
  • Assays built to cover GPCRs, Receptor Tyrosine Kinases, Signaling Pathways and Epigenetics Targets
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August 20, 2015 Simple, Functional Cell-Based Assays for Human Interleukins and Their Receptors - 60 min.

What will be covered?

  • Creation of functional cell-based assays for interleukins and their receptors
  • Application, development and validation of assays
  • Validated functional assays for >80% of interleukins spanning every family
  • Use of these assays for Screening, QC lot release and NAb applications
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July 23, 2015 Measure Compound-Target Engagement using InCELL Hunter™ Assays - 30 min.

What will be covered

  • Overview of target engagement assays
  • Introduction to InCELL Hunter assays
  • Explore applications for kinase, epigenetic or other protein targets
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July 9, 2015 Profiling Immunomodulatory mAbs, Compounds and Combinations in Human Primary Cell-based Oncology Models - 30 min.

What will be covered

  • Overview of the BioMAP Immuno-Oncology/Oncology Systems
    • Host Stromal/Vascular - Tumor Microenvironment Biology
    • Inflammation/Immune Biology
    • Comparison to MLR (Mixed Lymphocyte Reaction) assays
    • Immunophenotypic analysis
  • Case studies of profiling Ab therapies (anti-PD-1, anti-CTLA-4, etc.) and preclinical compounds
  • Case studies of combination studiest
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June 26, 2015 BioMAP® Systems Phenotypic Drug Profiling: How does your drug perform in human primary cell systems? - 60 min.

What will be covered

  • How BioMAP systems creates a unique profile for your drug
  • Case studies using the screening technology platform
  • Applications for phenotypic drug discovery
  • Services offered for compound profiling
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June 25, 2015 Analysis of Pirfenidone, Nintedanib, Other Compounds and Combinations in Human Primary Cell-based Fibrosis Models - 30 min.

What will be covered

  • Overview of the BioMAP Fibrosis Systems
  • Case studies of IPF drugs, their combination and other fibrosis related compounds using the screening technology platform
  • Applications for phenotypic drug discovery and compound profiling
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June 19, 2015 ヒト・インターロイキン受容体を80%網羅するPathHunter®機能アッセイ系のご紹介 - 60 min.

eSeminarの課題:

  • インターロイキンのセルベースアッセイのご紹介
  • アッセイ系の応用、開発そしてバリデーションの解説
  • インターロイキン・ファミリーを80%以上網羅する幅広いメニュー
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June 11, 2015 Extracting Maximum Value from KINOMEscan®: Study Report Interpretation - 60 min.

What will be covered

  • Overview of the KINOMEscan technology platform
  • Explanation of the data included in the KINOMEscan study report
  • Designing efficient strategies for KINOMEscan screening
  • Data analysis overview: frequently overlooked data provided by scanMAX® screens
  • An introduction to a useful data visualization tool: TREEspot
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June 10, 2015 Functional Cell-Based Assays for >80% of the Human Interleukin Family and Their Receptors - 60 min.

What will be covered

  • Creation of functional cell-based assays for interleukins and their receptors
  • Application, development and validation of assays
  • Validated assays for >80% of interleukins spanning every family
  • Use of these assays for Screening, QC lot release and NAb applications
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June 4, 2015 Robust HitHunter® cAMP Assays for Biologics and Small Molecules - 30 min.

What will be covered?

  • Overview of our novel enzyme fragment complementation technology
  • Introduction to the assay principle
  • Explore several applications for basic research and drug discovery (performing molecular profiling and identifying allosteric modulators, partial agonists, neutralizing Abs and more)
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May 28, 2015 Functional Cell-Based Assays for >80% of the Human Interleukin Family and Their Receptors - 60 min.

What will be covered

  • Creation of functional cell-based assays for interleukins and their receptors
  • Application, development and validation of assays
  • Validated assays for >80% of interleukins spanning every family
  • Use of these assays for Screening, QC lot release and NAb applications
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May 14, 2015 GPCR Profiling: Approaches for Characterizing Ligand Bias - 60 min.

What will be covered

  • Capabilities overview of LeadHunter Discovery Services
  • How LeadHunter can be used to identify and characterize novel biased ligands
  • Discover how multiple pathways including ß-Arrestin can influence efficacy in vivo
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April 9, 2015 Simple Bioassays for Potency & Stability Testing of Biotherapeutics - 60 min.

What will be covered?

  • Creation of cell-based bioassays for potency and stability testing
  • Application, development & validation of assays
  • Validated assays for >30 Biosimilars, RTKs, GPCRs, Interleukins, TGF-beta superfamily & Cytokine receptors
  • Case studies on Avastin and Erythropoietin
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April 7, 2015 强有力的针对生物大分子化合物及小分子化合物配体的 HitHunter® cAMP 检测方法 - 30 min.

What will be covered?

  • 酶片段互补技术的概述
  • 检测原理介绍
  • 探讨本方法在基础研究及新药研发中的一些应用(展示分子特性及鉴定变构调节剂,部分激动剂,中和抗体等)
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April 3, 2015 3種の新規BioMAPサービスのご紹介:線維症・オンコロジー・コンビネーション評価パネル - 60 min.

eSeminarの課題:

  • BioMAPスクリーニング技術の概要
  • BioMAP 線維症システム、オンコロジーシステム及びコンビネーション評価システムのご紹介
  • ケーススタディ [免疫チェックポイント阻害剤のスクリーニング]
  • フェノタイプ創薬と化合物プロファイリングへの適用
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April 1, 2015 BioMAP® Systems: Human Primary Cell Based Disease and Tissue Models for Drug Discovery - 40 min.

What will be covered?

  • Overview of BioMAP® Technology Platform
  • Case studies and applications of phenotypic screening in drug discovery
  • Services offered for compound profiling
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March 19, 2015 Bioassays without cell culture? Simple, robust cell-based bioassays for biosimilars through cryopreserved ready-to-assay cells - 60 min.

What will be covered?

  • Technology for creation of cell based assays
  • Application, development & qualification for Potency & NAb assays
  • Use of frozen ready to assay cells for bioassay purpose
  • Case studies on bioassays for Bevacizumab, Insulin, Epo, Ustekinumab, GLP receptor agonists, among others
  • Available Bioassays for over 30 biosimilars
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March 11, 2015 Robust HitHunter® cAMP Assays for Biologics and Small Molecules - 30 min.

What will be covered?

  • Overview of our novel enzyme fragment complementation technology
  • Introduction to the assay principle
  • Explore several applications for basic research and drug discovery (performing molecular profiling and identifying allosteric modulators, partial agonists, neutralizing Abs and more)
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March 3, 2015 BioMAP® Systems for Investigative Toxicology & Safety Assessment: A chemical biology approach for elucidating mechanisms of adverse drug reactions in human primary cell disease models - 40 min.

What will be covered?

  • Introduction to the BioMAP Technology Platform
  • Discussion of the challenges of building high throughput, physiologically relevant assays
  • Description of methods for analysis of large, phenotypic assay data sets
  • Case study:  the discovery of a novel mechanism underlying thrombosis-related side effects
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February 19, 2015 Human Primary Cell BioMAP® Systems for Drug Discovery - 60 min.

What will be covered?

  • Overview of the BioMAP systems
  • Case studies using the screening technology platform
  • Applications for phenotypic drug discovery
  • Services offered for compound profiling
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February 18, 2015 GPCR Profiling: A Robust Approach to Screening and Functional Characterization of GPCR Modulator - 60 min.

What will be covered

  • Capabilities overview of LeadHunter Discovery Services
  • Explore how LeadHunter can be used to triage hits, rank order compounds and develop novel biased ligands
  • Discover how multiple pathways including ß-Arrestin can influence efficacy in vivo
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February 11, 2015 Robust cell-based assays for detection of neutralizing anti-drug antibodies to follow on biologics like Insulin, GLP1 and Avastin - 60 min.

What will be covered?

  • Technology for creation of novel cell based assays
  • Application, development & validation of NAb assays
  • Applications to various targets, including GPCRs RTKs & Cytokine receptors
  • Case studies on GPCR & Cytokine Receptor target
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December 17, 2014 Validated Bioassays for Potency & Stability Testing of Biotherapeutics - 60 min.

What will be covered?

  • Creation of cell-based bioassays for potency and stability testing
  • Application, development & validation of assays
  • Validated assays for >30 Biosimilars, RTKs, GPCRs, Interleukins, TGF-beta superfamily & Cytokine receptors
  • Case studies on Avastin and Erythropoietin
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November 21, 2014 標準納期2週間を誇るKINOMEscan受託試験:報告書から抽出できる更なるデータ? - 60 min.

eSeminarの課題:


  • 納品物である、試験報告書の詳細
  • KINOMEscanアッセイ原理の詳細
  • データ解析法の紹介
  • scanMAX報告書から得られる、裏データ・裏情報
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November 18, 2014 Webinar: Efficient design and interpretation of KINOMEscan® inhibitor profiling experiments - 60 min.

What will be covered?

  • Overview of the KINOMEscan assay technology
  • Experimental design:  strategies for choosing a screening concentration
  • Interpretation of screening data: what to study and what to ignore
  • Predicting inhibitor affinities from single point screening data
  • Efficient strategies for designing follow-up experiments
  • Selectivity is in the eye of the beholder: data visualization using TREEspot™ and Scatter Plots
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November 12, 2014 Webinar: Detection of Cytokine and Growth Factor Receptor Dimerization Using Enzyme Fragment Complementation - 60 min.

What will be covered

  • Technology for creation of novel cell based assays
  • Application, development & validation of assays
  • Applications to various targets, including RTKs, TGF-beta superfamily & Cytokine receptors
  • Case studies on Cytokine Receptor & RTK targets
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October 23, 2014 Webinar: Analysis of α-PD-1, α-PD-L1 and Yervoy® (ipilimumab/α-CTLA-4) Immune Check Point Antibodies in Human Primary Cell BioMAP® Oncology Systems - 30 min.

What will be covered

  • Overview of the BioMAP Oncology Systems
  • Case studies of immune check point antibodies using the screening technology platform
  • Applications for phenotypic drug discovery and compound profiling
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October 16, 2014 GPCR Profiling: A Robust Approach to Screening and Functional Characterization of GPCR Modulators - 60 min.
<h4>What will be covered?</h4> <ul> <li> Capabilities overview of LeadHunter Discovery Services</li> <li> Explore how LeadHunter can be used to triage hits, rank order compounds and develop novel biased ligands</li> <li> Discover how multiple pathways including ß-Arrestin can influence efficacy in vivo</li> </ul>
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October 2, 2014 Pharmacotrafficking Webinar: Identify Pharmacochaperones to Rescue Misfolded CFTR and Other Proteins - 60 min.

What will be covered

  • Overview of protein trafficking and protein misfolding diseases
  • Description of our novel enzyme fragment complementation technology to monitor trafficking of proteins
  • Assay validation (ADRB2)
  • Case studies (CFTR and more)
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September 26, 2014 DiscoverX GPCR Profiling Services:迅速で高再現性を誇るGPCRスクリーニング&プロファイリング受託サービス - 60 min.
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September 25, 2014 Analysis of α-PD-1, α-PD-L1 and Yervoy® (ipilimumab/α-CTLA-4) Immune Check Point Antibodies in Human Primary Cell BioMAP® Oncology Systems - 53 min.

What will be covered

  • Overview of the BioMAP Oncology Systems
  • Case studies of immune check point antibodies using the screening technology platform
  • Applications for phenotypic drug discovery and compound profiling
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September 24, 2014 Dimerization Webinar: Detection of Cytokine and Growth Factor Receptor Dimerization Using Enzyme Fragment Complementation - 60 min.

What will be covered

  • Technology for creation of novel cell based assays
  • Application, development & validation of assays
  • Applications to various targets, including RTKs, TGF-beta superfamily & Cytokine receptors
  • Case studies on Cytokine Receptor & RTK targets
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August 20, 2014 Pharmacotrafficking Webinar: Identify Pharmacochaperones to Rescue Misfolded CFTR and Other Proteins - 60 min.

What will be covered?

  • Overview of protein trafficking and protein misfolding diseases
  • Description of our novel enzyme fragment complementation technology to monitor trafficking of proteins
  • Assay validation (ADRB2)
  • Case studies (CFTR and more)
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July 31, 2014 BioMAP Webinar: Human Primary Cell BioMAP® Systems for Drug Discovery - 60 min.

What will be covered?

• Overview of the BioMAP systems
• Case studies using the screening technology platform
• Applications for phenotypic drug discovery
• Services offered for compound profiling
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July 17, 2014 Dimerization Webinar: Detection of Cytokine and Growth Factor Receptor Dimerization Using Enzyme Fragment Complementation - 60 min.

What will be covered?

• Overview of the BioMAP systems
• Case studies using the screening technology platform
• Applications for phenotypic drug discovery
• Services offered for compound profiling
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July 11, 2014 BioMAP Predictive Toxパネル:被験物質・化合物の毒性や副作用を予測 - 60 min.

eSeminarの課題:


•        創薬や医薬品開発のための初代培養細胞をベースにしたPhenotypeスクリーニングの紹介。
•        Predictive Toxパネルで医薬化合物・物質の安全性や毒性を迅速に測定。
•        Predictive Toxパネルの様々な症例研究を紹介。
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July 1, 2014 GPCR Profiling - A Robust Approach to Screening and Functional Characterization of GPCR Modulators - 60 min.

What is covered

• Capabilities overview of LeadHunter Discovery Services
• Explore how LeadHunter can be used to triage hits, rank order compounds and develop novel biased ligands
• Discover how multiple pathways including ß-Arrestin can influence efficacy in vivo
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June 25, 2014 Biologics Webinar: Simple, Serum-tolerant Cell-based Assays to Detect Neutralizing Antibodies to a Biologic Drug - 60 min.

What will be covered?

• Technology for creation of novel cell based assays
• Application, development & validation of NAb assays
• Applications to various targets, including GPCRs RTKs & Cytokine receptors
• Case studies on GPCR & Cytokine Receptor target
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June 12, 2014 DiscoveRx & SGC Epigenetics Symposium
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May 30, 2014 BioMAP Predictive Toxパネル:被験物質・化合物の毒性や副作用を予測 - 30 min.

eSeminarの課題:


•        創薬や医薬品開発のための初代培養細胞をベースにしたPhenotypeスクリーニングの紹介。
•        Predictive Toxパネルで医薬化合物・物質の安全性や毒性を迅速に測定。
•        Predictive Toxパネルの様々な症例研究を紹介。
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April 30, 2014 Direct Measurement of Drug-Target Engagement in Live Cells Using InCELL Hunter™ Technology - 60 min.

What is Covered

  • Understand the InCELL Hunter technology platform
  • Learn how to develop your own intracellular binding assays for methyltransferase, bromodomain and kinase proteins
  • Explore case studies for target engagement of ATP-competitive and allosteric kinase inhibitors
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April 3, 2014 BioMAP® Systems for Investigative Toxicology & Safety Assessment - 60 min.

What will be covered?

• Overview of the BioMAP® platform
• Case studies relevant to safety assessment
• Compound Profiling Services using the Predictive Tox panel
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March 28, 2014 KINOMEscan: キナーゼ阻害剤の探索・解析に最適なスクリーニングサービス - 45 min.
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March 27, 2014 Direct Measurement of Drug-Target Engagement in Live Cells Using InCELL Hunter™ Technology - 60 min.

What will be covered?

  • Understand the InCELL Hunter technology platform
  • Learn how to develop your own intracellular binding assays for methyltransferase, bromodomain and kinase proteins
  • Explore case studies for target engagement of ATP-competitive and allosteric kinase inhibitors
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March 26, 2014 Extracting Maximum Value from KINOMEscan: Study Report Interpretation - 60 min.

What will be covered?

  • Overview of the KINOMEscan assay technology
  • Analysis of the KINOMEscan study report and included data information
  • Refresher on efficient strategies for designing KINOMEscan experiments
  • Data analysis overview:  frequently overlooked data provided by scanMAX screens
  • Data visualization tools: TREEspot
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March 19, 2014 GPCR Webinar: Multi-Pathway GPCR Screening to Quantify Ligand Bias - 60 min.

What will be covered?

• Understand the utility of the three core technology platforms
• Learn how to uncover biased ligands by characterizing the same GPCR target in multiple pathway readouts
• Explore case studies on OPRD1, OPRM1, S1P1, Glucagon and Chemokine receptors
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March 6, 2014 BioMAP®: Primary Human Cell Systems for Phenotypic Drug Discovery - 60 min.
<h4>What will be covered?</h4> &bull; Overview of the BioMAP system<br /> &bull; Case studies using the platform<br /> &bull; Applications for phenotypic drug discovery<br /> &bull; Compound profiling services
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February 27, 2014 GPCR Webinar: Multi-Pathway GPCR Screening to Quantify Ligand Bias - 60 min.

What will be covered?

• Understand the utility of the three core technology platforms
• Learn how to uncover biased ligands by characterizing the same GPCR target in multiple pathway readouts
• Explore case studies on OPRD1, OPRM1, S1P1, Glucagon and Chemokine receptors
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February 21, 2014 基于ß-Arrestin的GPCR激活检测方法以及GPCR药物研发前景 - 60 min.

内容包括

  • 如何将Arrestin技术和其他GPCR筛选技术结合以进行初期筛选结果验证,
  • 化合物作用机理研究,
  • 化合物副作用研究,
  • 大分子药物和生物标记检测等。
  • 还有关于孤儿受体GPCR的个案研究。
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February 20, 2014 GPCR Webinar: Internalization & Receptor Recycling - Essential Tools for GPCR Biology - 60 min.

What will be covered?

• Understand the PathHunter GPCR Internalization technology
• Discover how PathHunter can be used to differentiate between strongly internalizing & weakly internalizing compounds
• Explore how receptor trafficking and localization can impact the biological efficacy of a ligand
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February 19, 2014 Validated Cell-Based Assays for Functional Screening and Characterization of Therapeutic Antibodies - 60 min.

What will be covered?

• Overview of the technology platform
• Development, validation and application of assays
• Applications to GPCR & RTK antibody screening and profiling
• Case studies on CXCR3, CXCR4, ErbB1, ErbB2-ErbB3 and other targets
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February 14, 2014 [Chinese] 基于ß-Arrestin的GPCR激活检测方法以及GPCR药物研发前景 - 60 min.

内容包括:
  • 如何将Arrestin技术和其他GPCR筛选技术结合以进行初期筛选结果验证
  • 化合物作用机理研究
  • 化合物副作用研究
  • 大分子药物和生物标记检测
  • 关于孤儿受体GPCR的个案研究
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January 31, 2014 [Mini Webinar] BioMAP: ヒト由来プライマリー細胞ベースの疾患モデルを用いた、表現型創薬と新薬開発のスクリーニング系 - 30 min.
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January 29, 2014 Validated Cell-Based Assays for Functional Screening and Characterization of Therapeutic Antibodies - 60 min.

What will be covered?

• Overview of the technology platform
• Development, validation and application of assays
• Applications to GPCR & RTK antibody screening and profiling
• Case studies on CXCR3, CXCR4, ErbB1, ErbB2-ErbB3 and other targets
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December 12, 2013 Biologics Webinar: Cell-Based Assays for Functional Screening & Characterization of Therapeutic Antibodies - 60 min.

What will be covered?

• Overview of the technology platform
• Development, validation and application of assays
• Applications to GPCR & RTK antibody screening and profiling
• Case studies on CXCR3, CXCR4, ErbB1, ErbB2-ErbB3 and other targets
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December 4, 2013 GPCR Webinar: Internalization and Receptor Recycling - New Tools for GPCR Biology - 60 min.

What will be covered?

• Understand the PathHunter GPCR Internalization technology
• Discover how PathHunter can be used to differentiate between strongly internalizing & weakly internalizing compounds
• Explore how receptor trafficking and localization can impact the biological efficacy of a ligand
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November 29, 2013 KINOMEscan—一种高效的蛋白激酶抑制剂研发平台 - 60 min.

内容包括:

  • KINOMEscan 技术综述
  • 激酶抑制剂同激酶结合状态的重要性和基于活化状态的激酶抑制剂结合
  • 激酶抑制剂结合和脱离的动力学
  • 70个已知蛋白激酶抑制剂在Kinome水平的特异性分布:我们从中可以了解什么?
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November 21, 2013 BioMAP Webinar: Leveraging Predictive Human Adaptive Immune Cell Models for Drug Discovery - 60 min.

What will be covered?

• Overview of the BioMAP system
• Case Studies using the platform
• T-Cell Autoimmune Panel – including immunosuppression, inflammation & tissue remodeling
• Compound Profiling Services
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November 13, 2013 GPCR Webinar: Internalization & Receptor Recycling - New Tools for GPCR Biology - 60 min.

What will be covered?

• Understand the PathHunter GPCR Internalization technology
• Discover how PathHunter can be used to differentiate between strongly internalizing & weakly internalizing compounds
• Explore how receptor trafficking and localization can impact the biological efficacy of a ligand
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November 7, 2013 Simple Cell-Based Assays for Complex Signaling Pathways in Oncology, ER Stress and Anti-Oxidant Response - 60 min.

What will be covered?

• Overview of the PathHunter® pathway platform
• Key assay benefits
• Assay design and application
• Case studies on Keap-NRF2, XBP1 and NFkB pathways
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October 30, 2013 Epigenetic Webinar: Identification of Best-In-Class Bromodomain Inhibitors Using BROMOscan® Quantitative Ligand Binding Assays - 60 min.

What will be covered?

• Understand the BROMOscan technology platform
• Discover how BROMOscan can be applied to HTS, selectivity profiling and quantitative affinity (Kd) assessment
• Explore polypharmacology and the implications of dual inhibitors
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October 17, 2013 Introduction to BioMAP®: Predictive Human Disease Systems for Phenotypic Drug Discovery - 60 min.

What will be covered?

• Overview of the BioMAP system
• Case Studies using the platform
• Compound Profiling Services
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October 4, 2013 [Mini Webinar] GPCR educational series: Arrestin signaling - 30 min.

What will be covered?

• Understand the  PathHunter™ ß-Arrestin technology
• Discover how ß-Arrestin signaling correlates with compound activity in vivo
• Explore the potential of Arrestin-targeting therapeutics and the wealth of information it may unlock about compound behavior
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October 2, 2013 Validated Cell-Based Assays for Functional Screening and Characterization of Therapeutic Antibodies & Other Biologics - 60 min.

What will be covered?

• Overview of the technology platform
• Development, validation and application of assays
• Applications to GPCR & RTK antibody screening and profiling
• Case studies on CXCR3, CXCR4, ErbB1, ErbB2-ErbB3 and other targets
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September 18, 2013 GPCR Webinar: ß-Arrestin Signaling - The Pathway To Smarter, Safer and More Effective Drugs 09/18 - 60 min.

What will be covered?

• Understand the  PathHunter™ ß-Arrestin technology
• Discover how ß-Arrestin signaling correlates with compound activity in vivo
• Explore how Arrestin can be used to triage hits, rank order compounds & develop novel biased ligands
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September 11, 2013 Efficient design and interpretation of KINOMEscan® inhibitor profiling experiments - 60 min.

What will be covered?

  • Overview of the KINOMEscan assay technology
  • Experimental design:  strategies for choosing a screening concentration
  • Interpretation of screening data: what to study and what to ignore
  • Predicting inhibitor affinities from single point screening data
  • Efficient strategies for designing follow-up experiments
  • Selectivity is in the eye of the beholder: data visualization using TREEspot™ and Scatter Plots
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August 28, 2013 GPCR Webinar: ß-Arrestin Signaling - The Pathway To Smarter, Safer and More Effective Drugs - 60 min.

What will be covered?

• Understand the  PathHunter™ ß-Arrestin technology
• Discover how ß-Arrestin signaling correlates with compound activity in vivo
• Explore how Arrestin can be used to triage hits, rank order compounds & develop novel biased ligands
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August 14, 2013 BioMAP® Systems: Human Primary Cells Systems for Phenotypic Drug Discovery - 60 min.

What will be covered?

  • Overview of the BioMAP systems
  • Case studies using the screening technology platform
  • Applications for phenotypic drug discovery
  • Services offered for compound profiling
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July 26, 2013 Introduction to the BioMAP® Platform: Primary Human Cell Systems for Drug Discovery - 60 min.

What will be covered?

We will introduce the BioMAP Platform and present examples of how the primary human cell-based systems have provided insights into the drug discovery and development process, as well as enable biomarker discovery and validation.
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July 24, 2013 A Robust Experimental Approach for Efficient Development of Best-in-Class Kinase Inhibitors - 60 min.

What will be covered?

• Overview of the KINOMEscan assay technology
• Importance of understanding inhibitor binding mode & the activation state-dependence of binding
• Importance of understanding inhibitor association and dissociation kinetics
• Kinome-wide selectivity patterns for 70 mature kinase inhibitors: what have we learned?
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July 17, 2013 GPCR Webinar: ß-Arrestin Signaling - The Pathway To Smarter, Safer and More Effective Drugs
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June 5, 2013 Epigenetic Webinar: Human Cell Model Systems & Novel In Vitro Assays for Epigenetic Drug Discovery - 60 min.

What will be covered?

• Understand the BROMOscanSM and InCELL Hunter™ screening technologies
• Discover how BioMAP® signatures can predict compound safety and efficacy
• Explore how an integrated strategy of SAR, cellular activity and primary human cell model systems can be used to develop novel bromodomain and HDAC inhibitors
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May 30, 2013 Large Molecule Webinar: Validated Cell-Based Assays for Rapid Screening and Functional Characterization - 60 min.

What will be covered?

• Overview of the technology platform
• Development, validation and application of assays
• Applications to GPCR & RTK antibody screening and profiling
• Case studies on CXCR3, CXCR4, ErbB1, ErbB2-ErbB3 and other targets
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May 29, 2013 GPCR Webinar: ß-Arrestin Signaling - The Pathway To Smarter, Safer and More Effective Drugs - 60 min.

What will be covered?

• Understand the  PathHunter™ ß-Arrestin technology
• Discover how ß-Arrestin signaling correlates with compound activity in vivo
• Explore how Arrestin can be used to triage hits, rank order compounds & develop novel biased ligands
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May 16, 2013 Beyond Potency & Selectivity: Why Are Binding Kinetics Valuable In Kinase Drug Discovery? - 60 min.

What will be covered?

• KINOMEscan Technology: Applications for selectivity & potency optimization
scanMODE: Technology overview and applications
scanKINETIC: Technology overview and applications
• Key platform benefits
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May 14, 2013 Antibody Therapeutics Webinar: Validated Cell-Based Assays for Rapid Screening & Functional Characterization
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May 2, 2013 Epigenetic Webinar: Targeting Epigenetics & Cancer Using Human Cell Model Systems and Novel In Vitro Assays - 60 min.

What will be covered?

• Understand the BROMOscanSM and InCELL Hunter™ screening technologies
• Discover how BioMAP® signatures can predict compound safety and efficacy
• Explore how an integrated strategy of SAR, cellular activity and primary human cell model systems can be used to develop novel bromodomain and HDAC inhibitors
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March 28, 2013 Large Molecule Webinar: Validated Cell-Based Assays for Rapid Screening and Functional Characterization of Monoclonal Antibodies - 60 min.

What will be covered?

• Overview of the technology platform
• Development, validation and application of assays
• Applications to GPCR & RTK antibody screening and profiling
• Case studies on CXCR3, CXCR4, ErbB1, ErbB2-ErbB3 and other targets
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March 22, 2013 How Will You Integrate Arrestin Into Your GPCR Programs This Year? - 60 min.

What will be covered?

• Description of the PathHunter Arrestin technology
• Key platform benefits
• Assay design and validation strategies
• Case studies showing correlation between in vitro and in vivo studies
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March 19, 2013 Beyond Potency & Selectivity: Why Are Binding Kinetics Valuable In Kinase Drug Discovery? - 60 min.

What will be covered?

• KINOMEscan Technology: Applications for selectivity & potency optimization
scanMODE: Technology overview and applications
scanKINETIC: Technology overview and applications
• Key platform benefits
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March 7, 2013 Beyond the BET Family: Biochemical and Cell-Based Solutions for Targeting Bromodomains - 60 min.

What will be covered?

• Overview of the BROMOscan and InCELL Hunter technologies
• Key platform benefits
• Assay design and validation strategies
• Application to HTS, selectivity profiling, and quantitative affinity (Kd) determinations
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February 27, 2013 Identify Hidden Aspects of Compound Activity Using PathHunter® Arrestin - 60 min.

What will be covered?

• Description of the PathHunter Arrestin technology
• Key platform benefits
• Assay design and validation strategies
• Case studies showing correlation between in vitro and in vivo studies
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February 27, 2013 How Will You Integrate Arrestin Into Your GPCR Programs This Year? - 60 min.

What will be covered?

• Description of the PathHunter Arrestin technology
• Key platform benefits
• Assay design and validation strategies
• Case studies showing correlation between in vitro and in vivo studies
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February 14, 2013 Introduction to the BioMAP® Platform: Primary Human Cell Systems for Drug Discovery - 60 min.

What will be covered?

• Overview of the BioMAP system
• Case Studies using the platform
• Compound Profiling Services
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January 30, 2013 Functional Pathway Assays for Oncology Research: Simple Cell-Based Tools to Study Complex Pathways - 60 min.

What will be covered?

• Overview of the PathHunter® pathway platform
• Key assay benefits
• Assay design and application
• Case studies on Keap-NRF2, PI3, Wnt-Frizzled and p53 pathwayss
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November 14, 2012 BROMOscan – A High Throughput, Biochemical Screening Platform for Identification of Best-In-Class Bromodomain Inhibitors - 60 min.

What will be covered?

  • Overview of the BROMOscan℠ technology platform
  • Inhibitor binding assays for the BET family and other diverse bromodomain targets
  • Assay validation strategies
  • Application to HTS, selectivity profiling and quantitative affinity (Kd) determinations
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