DAPK2, active

N-terminal GST-tagged recombinant, human full length DAPK2.

Catalog #: 14-657

$399.00$2,989.00


Inquire
Biological Information
Background Information:
Death-associated protein kinase (DAPK) is a calcium/calmodulin-dependent kinase that phosphorylates serine/threonine residues on proteins. DAPK modulates cell death induced by IFN-g, TNF-a, Fas, and detachment from the extracellular matrix. DAPK has been also implicated in TGF-induced apoptosis in several cultured cell lines in which Smad proteins mediate transcriptional activation of DAPK. A member of DAP kinase family, DAPK2 is a 42 KDa calcium/calmodulin-dependent serine/threonine kinase localized in the cytoplasm. Reports suggest DAPK2 along with DAPK1 induces membrane blebbing and formation of autophagic vesicles and plays a vital role in TGF-induced caspase-dependent Type-I and IFNγ-induced caspase-independent autophagic type II cell death signaling. Inhibition of DAPK2 may facilitate tumor progression. GenBank NM_014326
Target Class:
Kinase
Accession Number:
NM_014326.3
Target Name:
DAPK2
Target Aliases:
DAPK2, DRP-1, MGC119312
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Datasheets

14-657x Datasheet

View Document