Biological Information | |
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Background Information: | LOK, also known as STK10 (Serine/Threonine Kinase 10), a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like Kinase kinases. LOK can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. LOK can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein Kinase kinase 1 pathway.
GenBank NM_005990 |
Target Class: | Kinase |
Accession Number: | NM_005990.3 |
Target Name: | LOK |
Target Aliases: | STK10, PRO2729, LOK |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
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