Pyk2, active

N-terminal 6His-tagged recombinant, human full length Pyk2.

Catalog #: 14-567

$399.00$2,989.00


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Biological Information
Background Information:
Proline-rich tyrosine kinase 2 (PTK2B) (also called CAKb for cell adhesion kinase b, RAFTK for related adhesion focal tyrosine kinase, or CADTK for calcium-dependent tyrosine kinase) is a non-receptor tyrosine kinase structurally related to focal adhesion kinase (FAK). PTK2B interacts with Src family kinases and focal adhesion proteins such as p130Crk-associated substrate (p130Cas) and its homologue p105 human enhancer of filamentation 1 (HEF1). PTK2B is particularly enriched in pulmonary vascular endothelial cells and lung, a major organ site for tumor metastasis. Inhibitors of PTK2B may be useful in the treatment of lung cancer. GenBank S80542
Target Class:
Kinase
Family:
Cytosolic Tyrosine Kinase
Accession Number:
NM_004103.3; NM_173174.1; NM_173175.1; NM_173176.1
Target Name:
PYK2
Target Aliases:
PTK2B, RAFTK, FAK2, PYK2, FADK2, PTK, CADTK, CAKB, PKB
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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Datasheets

14-567x Datasheet

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