KILR® Cytotoxicity CD16 Effector Cells

Driving Robust and Reproducible ADCC and T-Cell Redirection

Effector cells such as peripheral blood mononuclear cells (PBMCs) have inherent donor variability, reducing consistency and reproducibility in lot release assays. Antibody-Dependent Cell Cytotoxicity (ADCC) assays that measure cell death often have low signal-to-background (S/B) ratios and suffer from this donor variability of the PBMCs.

Eurofins DiscoverX® offers KILR CD16 Effector Cells are single donor-derived human primary cells. They are ideal for measuring target cell death using ADCC or bi-specific antibody-mediated T-cell redirection (TCR) for screening, characterization, and QC lot release of immunotherapeutics (antibody drugs). These effector cells ensure assay reproducibility with higher S/B ratios, eliminating donor variability.

Product Highlights
  • Eliminate Donor Variability – Primary effector cells (human cytotoxic T lymphocytes) from a single donor engineered to stably express CD16 (V158)
  • Fit for Long-Term QC Testing – Uniformly manufactured to ensure lot-to-lot consistency and produce high S/B ratios
  • Measure Target Cell Death – High killing capacity for implementing ADCC or TCR for lot release or characterization

Consider Eurofins DiscoverX’s custom development capabilities for custom cell lines, assays, & enzyme development.

Highlights