ChemiSCREEN™ SST2 Somatostatin Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ SST2 Somatostatin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. somatostatin) based activation of SSTR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses SSTR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of SSTR2 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Somatostatin

Sub Family:

Class A

Protein Name:

sst2

Protein Aliases:

SS2-R|SS2R|SRIF-1

Accession Number:

NM_001050.2

UniProt Number:

P30874

Gene Name:

SSTR2

Gene ID:

6752

Target Species:

Human

Cell Background:

Chem-1