CAMP Hunter™ CHO-K1 LHCGR Bioassay Kit

Background Information:

The cAMP Hunter™ CHO-K1 LHCGR Bioassay Kit an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. HLH) based activation of LHCGR activity via detection of levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type LHCGR, a Gαs-coupled receptor. Upon activation of LHCGR, the (decrease/increase) in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.

Target Class:

GPCR

Family:

Glycoprotein Hormone

Sub Family:

Class A

Protein Name:

LH

Protein Aliases:

Luteinizing hormone receptor|LHR|LSH-R

Accession Number:

NM_000233

UniProt Number:

P22888

Gene Name:

LHCGR

Gene ID:

3973

Gene Aliases:

LHR|LCGR|LGR2|ULG5|LGR2|LHRHR

Target Species:

Human

Cell Background:

CHO-K1