cAMP Hunter™ CHO-K1 TAAR1 Gs Cell Line

Background Information:

The cAMP Hunter™ TAAR1 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. p-tyramine) based activation of TAAR1 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type TAAR1 , a naturally Gs coupled GPCR. Upon activation of TAAR1 , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Trace Amine

Sub Family:

Class A

Coupling:

Gs

Protein Name:

TA1

Protein Aliases:

Trace amine receptor 1

Accession Number:

NM_138327.1

UniProt Number:

Q96RJ0

Gene Name:

TAAR1

Gene ID:

134864

Gene Aliases:

TAR1|TA1

Target Species:

Human

Cell Background:

CHO-K1