ChemiSCREEN™ ChemR23 Chemoattractant Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ ChemR23 Chemoattractant Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. chemerin) based activation of CMKLR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CMKLR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CMKLR1 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Chemerin

Sub Family:

Class A

Protein Name:

ChemR23

Protein Aliases:

resolvin E1 receptor|chemerin receptor

Accession Number:

NM_004072

UniProt Number:

Q99788

Gene Name:

CMKLR1

Gene ID:

1240

Gene Aliases:

RVER1|CHEMR23|DEZ

Target Species:

Human

Cell Background:

Chem-1