ChemiSCREEN™ NK3 Tachykinin Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ NK3 Tachykinin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. tachykinins) based activation of TACR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses TACR3 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of TACR3 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Tachykinin

Sub Family:

Class A

Protein Name:

NK3

Protein Aliases:

neurokinin beta receptor

Accession Number:

NM_001059

UniProt Number:

P29371

Gene Name:

TACR3

Gene ID:

6870

Gene Aliases:

NK3R|TAC3R

Target Species:

Human

Cell Background:

Chem-1