InCELL Hunter™ eXpress CSF1R Kinase Binding Assay

Background Information:

The InCELL Hunter™ eXpress CSF1R Kinase Binding Assay provides an easy-to-use cell based assay to study small molecule drug candidates that engage with kinases. This kit assesses compound-engagement-based stabilization of CSF1R via detection of CSF1R levels. This product uses EFC technology. The cells included overexpress CSF1R target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

Fms (CSFR)

Protein Aliases:

CSF-1-R|CSF-1R|M-CSF-R|Proto-oncogene c-Fms|CD antigen CD115

Accession Number:

NC_000005.10

UniProt Number:

P07333

Gene Name:

CSF1R

Gene ID:

1436

Gene Aliases:

C-FMS|CSFR|CD115

Target Species:

Human

Cell Background:

A549