MAP Kinase 1/Erk2, active

Background Information:

MAPK1 (mitogen-activated protein kinase 1, ERK2 or extracellular signal &-regulated protein kinase) is one of the isoforms of MAP kinase. This serine/threonine kinase is activated by dual phosphorylation on tyrosine and threonine residues (Tyr-185 and Thr-183). Phosphorylation of both residues by the upstream activator MEK (mitogen-activated protein Kinase kinase, MAP2K) is essential not only for ERK2 activation, but also for translocation of the ERK2 to the nucleus. Following this activation, ERK2 phosphorylates a large number of regulatory proteins and this directly controls key cellular processes such as transcription, translation and cytoskeletal rearrangement. An inhibitor assay may be of benefit for the treatment of cancer, diabetes, neurodegenerative disorders or asthma. GenBank NM_002745 (amino acid sequence only)

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

ERK2

Protein Aliases:

MAPK 1|Extracellular signal-regulated kinase 2|ERK-2|MAP kinase isoform p42|p42-MAPK|Mitogen-activated protein kinase 2|MAP kinase 2|MAPK 2

Accession Number:

NM_002745.4; NM_138957.2

UniProt Number:

P28482

Gene Name:

MAPK1

Gene ID:

5594

Gene Aliases:

ERK|ERK2|p41mapk|MAPK2|PRKM1|PRKM2

Target Species:

Human