MAP Kinase 1/Erk2 (MU), unactive

Background Information:

MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and post-mitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs.

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

ERK2

Protein Aliases:

MAPK 1|Extracellular signal-regulated kinase 2|ERK-2|MAP kinase isoform p42|p42-MAPK|Mitogen-activated protein kinase 2|MAP kinase 2|MAPK 2

Accession Number:

D10939

UniProt Number:

P63085

Gene Name:

Mapk1

Gene ID:

26413

Gene Aliases:

ERK|ERK2|p41mapk|MAPK2|PRKM1|PRKM2

Target Species:

Mouse