p53 (expressed in E.coli)

Background Information:

p53 is a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants. GenBank BC003596.1

Target Class:

DNA Repair & Mitotic Regulation

Family:

Tumor Suppressor Gene

Protein Name:

p53

Protein Aliases:

Li-Fraumeni syndrome

Accession Number:

BC003596.1

UniProt Number:

P04637

Gene Name:

TP53

Gene ID:

7157

Gene Aliases:

p53|LFS1

Target Species:

Human