PathHunter® BTLA Signaling Cell Line (Jurkat)

Background Information:

The PathHunter® BTLA Signaling Cell Line (Jurkat) is a stable, engineered cell line for use in studying molecules and drug candidates targeting signaling checkpoints. This cell line enables assessment of BTLA induced non-canonical NF-κB signaling via detection of SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged BTLA target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Checkpoint Receptor

Protein Name:

BTLA

Accession Number:

NM_181780.3

UniProt Number:

Q7Z6A9

Gene Name:

BTLA

Gene ID:

151888

Gene Aliases:

BTLA1|CD272

Target Species:

Human

Cell Background:

Jurkat