PathHunter® CHO-K1 GLP2R Bioassay Kit

Background Information:

The CHO-K1 PathHunter® GLP2R Bioassay kit provides a robust, highly sensitive, and easy-to-use functional cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. GLP2) based activation of GLP2R GPCR activity via detection of β-arrestin recruitment. The included cells overexpress ProLink-tagged GLP2R and EA-tagged β-Arrestin-2. Activation of GLP2R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.

Target Class:

GPCR

Family:

Glucagon

Sub Family:

Class B

Protein Name:

GLP-2

Protein Aliases:

GLP-2-R|GLP-2R

Accession Number:

NM_004246.1

UniProt Number:

O95838

Gene Name:

GLP2R

Gene ID:

9340

Target Species:

Human

Cell Background:

CHO-K1