PathHunter® HepG2 STAT3 Pathway Reporter Cell Line

Background Information:

The PathHunter® HepG2 STAT3 Pathway Reporter Cell Line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting the STAT3 pathway. This cell line enables assessment of STAT3 pathway stimulation based on changes in the expression of a STAT3 response element-driven reporter protein. This product uses EFC technology. The included cell line expresses PL-tagged reporter protein under the control of a STAT3 pathway-inducible transcriptional response element. Pathway activation induces expression of the PL-tagged protein, allowing detection of EFC signal upon addition of EA-containing detection reagent.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Nuclear Protein

Family:

Transcription factor

Sub Family:

STAT

Protein Name:

STAT3

Accession Number:

NM_139276.3

UniProt Number:

P40763

Gene Name:

STAT3

Gene ID:

6774

Gene Aliases:

APRF

Target Species:

Human

Cell Background:

HepG2