PathHunter® U2OS FcgRIIb Clustering Cell Line

Background Information:

The PathHunter® FcγRIIb clustering cell line is a stable, engineered cell line designed to increase signal produced from a Checkpoint Cell Line via antibody-mediated crosslinking of the receptors. This product is a companion product used to determine cross-linking based increases in potency of agonist antibodies. The cell line included overexpresses FcγRIIb Fcg receptor. When co-cultured with a Checkpoint Cell Line in the presence of agonist antibody, the Fcg receptor binds to the antibody, inducing receptor clustering. The induced receptor clustering leads to increased activation and downstream signaling, leading to increased EFC signal production.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Checkpoint Receptor

Family:

IgSF

Sub Family:

Immunoglobulin Fc Receptor

Protein Name:

FcgR2B

Protein Aliases:

CDw32|Fc-gamma RII-b|Fc-gamma-RIIb|FcRII-b|CD antigen CD32

Accession Number:

NM_004001.4

UniProt Number:

P31994

Gene Name:

FCGR2B

Gene ID:

2213

Gene Aliases:

CD32|FCG2|IGFR2

Target Species:

Human

Cell Background:

U2OS