PathHunter® U2OS IL31R/OSMRb Bioassay Kit

Background Information:

The PathHunter® OSMRb/IL31R Dimerization Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. IL-31) induced dimerization of OSMRb/IL31R receptors. This product uses EFC technology. The cell line included overexpresses OSMRb target protein fused to PK alongside IL31RA target protein fused to EA. Upon ligand-induced dimerization of OSMRb/IL31R, detectable EFC signal is produced. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.

Target Class:

Cytokine Receptor

Family:

IL-6 Receptor

Protein Name:

IL31RA

Protein Aliases:

IL-31R subunit alpha|IL-31R-alpha|IL-31RA|Cytokine receptor-like 3|GLM-R|hGLM-R|Gp130-like monocyte receptor|Gp130-like receptor|ZcytoR17

Accession Number:

NM_139017.5

UniProt Number:

Q8NI17

Gene Name:

IL31RA

Gene ID:

133396

Gene Aliases:

CRL3|GPL|UNQ6368/PRO21073/PRO21384

Target Species:

Human

Cell Background:

U2OS