PathHunter® U2OS mFcgRIIb Clustering Cell Line

Background Information:

The Path Hunter mFcyRIIb clustering cell line is a stable, engineered cell line designed to increase signal produced from a Checkpoint Cell Line via antibody-mediated crosslinking of the receptors. This product is a companion product used to determine cross-linking based increases in potency of agonist antibodies. The cell line included overexpresses mFcyRIIb Fcg receptor. When co-cultured with a Checkpoint Cell Line in the presence of agonist antibody, the Fcg receptor binds to the antibody, inducing receptor clustering. The induced receptor clustering leads to increased activation and downstream signaling, leading to increased EFC signal production.
This stable engineered cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.

Target Class:

Checkpoint Receptor

Family:

IgSF

Sub Family:

Immunoglobulin Fc Receptor

Protein Name:

FcgR2B

Protein Aliases:

Fc gamma receptor IIB (Fc-gamma RII|Fc-gamma-RIIB| FcRII)|IgG Fc receptor II beta|Lymphocyte antigen 17 (Ly-17)|CD32

Accession Number:

NM_001077189.1

UniProt Number:

P08101

Gene Name:

Fcgr2b

Gene ID:

14130

Gene Aliases:

CD32|Fcgr2|Fcr-2|Fcr-3|Ly-17|LyM-1|Lym-1|fcRII|FcgRII|Fcgr2a|Ly-m20|Fc[g]RII|F630109E10Rik

Target Species:

Mouse

Cell Background:

U2OS