BTK, active

N-terminal 6His-tagged recombinant, human full length BTK.

Catalog #: 14-552

$399.00$2,989.00


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Biological Information
Background Information:
BTK (Bruton's Tyrosine Kinase) is a member of the Tec family kinases which are important components of both antigen receptor signaling and other cell surface receptors, resulting in regulation of the actin cytoskeleton, adhesion, migration, and transcriptional activation. BTK is found in all cells of the hematopoietic lineage except plasma and T cells, and is required for normal B cell development and signal transduction through cell surface molecules. Mutations in the btk gene result in aberrant B cell development, leading to the X-linked agammaglobulinemia phenotype in humans and to the less severe X-linked immunodeficiency in mice. BTK inhibitors may be of benefit in the treatment of leukemias and lymphomas. GenBank NM_000061
Target Class:
Kinase
Family:
Tyrosine Kinase: TEC Family
Accession Number:
NM_000061.1
Target Name:
BTK
Target Aliases:
BTK, PSCTK1, MGC126261, ATK, XLA, IMD1, AT, OTTHUMP00000063593, BPK, MGC126262, AGMX1
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
Usage Disclaimer:
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Datasheets

14-552x Datasheet

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