Cdk3/Cyclin E, active

Complex of recombinant, human full length cdk3 containing a C-terminal 6His-tag, and recombinant, human full length cyclin E containing an N-terminal GST-tag.

Catalog #: 14-487

$399.00$2,989.00


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Biological Information
Background Information:
The cyclin-dependent kinases (CDKs), a subfamily of protein kinases, promote cell cycle progression. In mammals, nine different CDKs (cdk 1 to cdk 9; cdk 1 is better known as cdc 2) have been identified. CDKs are regulated on various levels including binding of proteins (cyclins, inhibitors, and assembly factors), protein degradation, transcriptional control, localization, and multiple phosphorylations. This leads to timely regulation of CDK activity, allowing progression from one cell cycle phase to the next. Cdk3 participates in the G1–S progression at least partially by binding to E2F-1, E2F-2, or E2F-3 through DP-1 and by enhancing their transcriptional activities. GenBank X66357 / GenBank NM_001238
Target Class:
Kinase
Family:
Serine/Threonine Kinase: CDK1 subfamily
Accession Number:
NM_001258.1
Target Name:
CDK3/cyclinE
Target Aliases:
CDK3
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
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Datasheets

14-487x Datasheet

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