Biological Information | |
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Background Information: | The cyclin-dependent kinases (CDKs), a subfamily of protein kinases, promote cell cycle progression. In mammals, nine different CDKs (cdk 1 to cdk 9; cdk 1 is better known as cdc 2) have been identified. CDKs are regulated on various levels including binding of proteins (cyclins, inhibitors, and assembly factors), protein degradation, transcriptional control, localization, and multiple phosphorylations. This leads to timely regulation of CDK activity, allowing progression from one cell cycle phase to the next. Cdk3 participates in the G1–S progression at least partially by binding to E2F-1, E2F-2, or E2F-3 through DP-1 and by enhancing their transcriptional activities.
GenBank X66357 / GenBank NM_001238 |
Target Class: | Kinase |
Family: | Serine/Threonine Kinase: CDK1 subfamily |
Accession Number: | NM_001258.1 |
Target Name: | CDK3/cyclinE |
Target Aliases: | CDK3 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 1 year at -70°C |
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Cdk3/Cyclin E, active
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