EGFR, active

N-terminal GST-tagged recombinant, human EGFR kinase domain amino acids 696-end.

Catalog #: 14-531

$399.00$2,989.00


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Biological Information
Background Information:
Receptors that are tyrosine protein kinases include those receptors for epidermal growth factor (EGF), platelet-derived growth factor (PDGF), insulin, and certain lymphokines. Receptor tyrosine kinases are cell surface transmembrane proteins responsible for intracellular signal transduction. They are expressed in many cell types and, after activation by growth factor binding, trigger a series of intracellular pathways leading to a wide variety of responses; e.g. differentiation, proliferation, migration and invasion, angiogenesis, survival. EGF receptor agonism may facilitate wound healing, enhance viral infections, topical inflammation and asthma as well as tumor cell proliferation and metastasis. GenBank X00588
Target Class:
Kinase
Family:
Receptor Typosine Kinase (RTK): Growth Factor Receptor
Accession Number:
NM_005228.3; NM_201282.1; NM_201283.1; NM_201284.1
Target Name:
EGFR
Target Aliases:
EGFR, ERBB1, ERBB, mENA
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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Datasheets

14-531x Datasheet

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