Biological Information | |
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Background Information: | Eph family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Recruitment of CrkII and activation of Rho Signaling are responsible for EphA3-mediated cell rounding, blebbing and de-adhesion. This response is activated by ephrin-A5-mediated receptor clustering and EphA3 tyrosine kinase activity.
GenBank NM_005233 |
Target Class: | Kinase |
Family: | Receptor Typosine Kinase (RTK): Growth Factor Receptor |
Accession Number: | NM_005233.3; NM_182644.1 |
Target Name: | EphA3 |
Target Aliases: | EPHA3, HEK4, ETK1, HEK, TYRO4, ETK, EphA3 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
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