ErbB2, active

10 µg of active ErbB2. C-terminal 6His-tagged recombinant, human ErbB2 amino acids 676-end.

Catalog #: 14-939

$399.00$2,989.00


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Biological Information
Background Information:
Human EGF receptor 2 (HER2, ERBB2) tyrosine kinase is an EGF receptor-related protein tyrosine kinase which is overexpressed in many mammary and ovarian carcinomas. Binding of the ligand to the receptor is believed to activate the receptor's intrinsic protein kinase activity, initiating a signal transduction pathway which leads to increased cell proliferation. Truncated HER2, lacking the extracellular and transmembrane regions, is constitutively active. The active kinase transfers g-phosphates of ATP to the phenolic hydroxyl of specific tyrosine residues on target proteins. GenBank NM_004448
Target Class:
Kinase
Family:
Receptor Typosine Kinase (RTK): Growth Factor Receptor
Accession Number:
NM_004448; G778D
Target Name:
ErbB2
Target Aliases:
ERBB2, HER2, NGL, NEU, HER-2, TKR1, MLN19
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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Datasheets

14-939x Datasheet

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