FAK, active

N-terminal 6His-tagged recombinant, human FAK amino acids 411-686.

Catalog #: 14-720

$399.00$2,989.00


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Biological Information
Background Information:
PTK2 (Protein Tyrosine Kinase 2, formerly FAK or Focal Adhesion Associated Protein Tyrosine Kinase) is a widely expressed non-receptor involved in the structure and function of focal adhesions, which are critical for cellular integrity by maintaining cell-cell and cell-matrix interactions. Integrin-mediated cell adhesion causes activation of MAP kinases and increased tyrosine phosphorylation of PTK2. Autophosphorylation of PTK2 leads to the binding of SH2-domain proteins including Src-family kinases and the Grb2-Sos complex, then activate Ras cascade and ultimately to mitogen activated protein (MAP) kinase activation. GenBank L13616
Target Class:
Kinase
Family:
Cytosolic Tyrosine Kinase
Accession Number:
NM_005607.3; NM_153831.2
Target Name:
FAK
Target Aliases:
PTK2, pp125FAK, FAK, FADK, FAK1
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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Datasheets

14-720x Datasheet

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