FGFR3, active

N-terminal 6His-tagged recombinant, human FGFR amino acids 447-761.

Catalog #: 14-464

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Biological Information
Background Information:
Fibroblast growth factor (FGF) superfamily consists of 23 members, all of which contain a conserved 120 amino acid (aa) core region that contains six identical, interspersed amino acids. Based on the pI factor, two main groups of FGF are named: acidic FGF (aFGF) and basic FGF (bFGF). The superfamily members act extracellularly through four tyrosine kinase FGF receptors (FGR1 through FGR4), with multiple specificities noted for almost all FGFs. Biological binding of aFGF to its receptors will result in phosphorylation of the receptor and non-receptor proteins and generate its function. FGR3 (FGFR-3, Fibroblast growth factor receptor 3, EC 2.7.1.112) is expressed mainly in bone, central nervous system and tumors. Inhibition of FGR3 may be useful in the treatment of dwarfism as well as some tumors. GenBank M58051
Target Class:
Kinase
Family:
Receptor Typosine Kinase (RTK): Growth Factor Receptor
Accession Number:
NM_000142.2; NM_022965.1
Target Name:
FGFR3
Target Aliases:
FGFR3, HSFGFR3EX, JTK4, FGFR-3, ACH, CEK2, CD333
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
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Datasheets

14-464x Datasheet

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