Biological Information | |
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Background Information: | GAK (Cyclin-G-associated kinase) is a serine/threonine protein kinase that is involved in the regulation of several cellular processes, including cell cycle progression, endocytosis, and Golgi complex organization.
GAK has been shown to phosphorylate several key proteins involved in the regulation of the cell cycle, including cyclin-dependent kinase 1 (CDK1) and its regulatory subunit cyclin B1.
Research has suggested that GAK may be involved in the development and progression of several diseases, including cancer and neurodegenerative disorders such as Parkinson's disease. In cancer, GAK has been shown to be upregulated in several types of cancer, and may play a role in the regulation of cancer cell growth and survival. In Parkinson's disease, GAK has been implicated in the regulation of the clearance of α-synuclein, a protein that forms abnormal aggregates in the brain of Parkinson's disease patients. |
Target Class: | Kinase |
Accession Number: | NM_005255.4 |
Target Name: | GAK |
Target Aliases: | Cyclin G Associated Kinase, DNAJC26, Cyclin-G-Associated Kinase, Auxilin-2, DNAJ26 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 1 year at -70°C |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
GAK, active
10 µg of active GAK. N-terminal FLAG-tagged and N-terminal 6His-tagged, recombinant, human GAK amino acids 12-347.
Datasheets
16-055x Datasheet
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