GAK, active

10 µg of active GAK. N-terminal FLAG-tagged and N-terminal 6His-tagged, recombinant, human GAK amino acids 12-347.

Catalog #: 16-055

$399.00$2,989.00


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Biological Information
Background Information:
GAK (Cyclin-G-associated kinase) is a serine/threonine protein kinase that is involved in the regulation of several cellular processes, including cell cycle progression, endocytosis, and Golgi complex organization. GAK has been shown to phosphorylate several key proteins involved in the regulation of the cell cycle, including cyclin-dependent kinase 1 (CDK1) and its regulatory subunit cyclin B1. Research has suggested that GAK may be involved in the development and progression of several diseases, including cancer and neurodegenerative disorders such as Parkinson's disease. In cancer, GAK has been shown to be upregulated in several types of cancer, and may play a role in the regulation of cancer cell growth and survival. In Parkinson's disease, GAK has been implicated in the regulation of the clearance of α-synuclein, a protein that forms abnormal aggregates in the brain of Parkinson's disease patients.
Target Class:
Kinase
Accession Number:
NM_005255.4
Target Name:
GAK
Target Aliases:
Cyclin G Associated Kinase, DNAJC26, Cyclin-G-Associated Kinase, Auxilin-2, DNAJ26
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
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Datasheets

16-055x Datasheet

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