JNK3/SAPK1b, active

N-terminal 6His-tagged recombinant, human full length JNK3/SAPK1b.

Catalog #: 14-501

$399.00$2,989.00


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Biological Information
Background Information:
c-Jun N-terminal kinases (JNKs), a stress-activated protein kinase (SAPK), is involved in cellular responses to environmental stresses. JNK kinases can be activated by stimuli such as UV light, radiation, protein synthesis inhibitors, ceramide, DNA-damaging drugs, chemopreventive drugs, TNF-a, and interleukin 1. JNK binds to an NH2-terminal region of ATF2 and c-Jun and phosphorylates two sites within the activation domain of each transcription factor. Three JNK genes (Jnk1, -2 and -3) have been identified in humans; however, splice variants result in a total of 10 isoforms. Inhibition of JNK3 (MAPK10, Mitogen-activated protein kinase 10, Stress-activated protein kinase JNK3) may provide clinical benefit in diseases as diverse as immune inflammatory (joint, bowel, pulmonary), ischemic injury (brain, cardiac) and neurodegenerative (Alzheimer's, Parkinson's) diseases.
Target Class:
Kinase
Family:
Ser/Thr Kinase; MAPK; JNK subfamily
Accession Number:
NM_002753.2; NM_138980.1; NM_138981.1; NM_138982.1
Target Name:
JNK3/SAPK1b
Target Aliases:
MAPK10, JNK3A, p54bSAPK, PRKM10, FLJ12099, JNK3, p493F12, MGC50974, FLJ33785
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
Usage Disclaimer:
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Datasheets

14-501x Datasheet

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