Lyn, active

N-terminal 6His-tagged recombinant, human full length Lyn.

Catalog #: 14-510

$399.00$2,989.00


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Biological Information
Background Information:
The Lyn protein is a member of the Src family of non-receptor-associated protein-tyrosine kinases. LYN A differs from LYN B in having an additional 21 amino acids at the amino terminus. Lyn undergoes a concentration-dependent autophosphorylation, thus activating the catalytic site and decreasing the accessibility of the SH2 domain. Lyn phosphorylates and activates Tec, non-receptor tyrosine kinase that is coexpressed with Lyn and acts downstream of Lyn in intracellular signaling pathways. Lyn tyrosine kinase has been shown to be necessary for IgE-receptor (FceRI)-mediated mast-cell activation. EMBL M16038
Target Class:
Kinase
Accession Number:
NM_002350.1
Target Name:
Lyn
Target Aliases:
LYN, JTK8, FLJ26625
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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Datasheets

14-510x Datasheet

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