Biological Information | |
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Background Information: | MLK3 is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008] |
Target Class: | Kinase |
Accession Number: | GenBank NM_002419.2 |
Target Name: | MLK3 |
Target Aliases: | Mitogen-Activated Protein Kinase Kinase Kinase 11, MEKK11, Src-Homology 3 Domain-Containing Proline-Rich Kinase, Mixed Lineage Kinase 3, SH3 Domain-Containing Proline-Rich Kinase, Protein-Tyrosine Kinase PTK1, EC 2.7.11 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 1 year at -70°C |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
MLK3, active
Active MLK3. N-terminal GST-tagged, recombinant, human MLK3 amino acids 1-468.
Datasheets
16-039x Datasheet
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