Biological Information | |
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Background Information: | mTOR (Mechanistic Target Of Rapamycin Kinase) belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections.
GenBank NM_004958 |
Target Class: | Kinase |
Accession Number: | NM_004958.2 |
Target Name: | mTOR (FRAP1) |
Target Aliases: | FRAP1, RAPT1, MTOR, FRAP, mTOR, FLJ44809, FRAP2, RAFT1 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 1 year at -70°C |
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