mTOR (1362-end), active

N-terminal FLAG-tagged recombinant, human mTOR amino acids 1362-end.

Catalog #: 14-770

$699.00$2,989.00


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Biological Information
Background Information:
mTOR (Mechanistic Target Of Rapamycin Kinase) belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. GenBank NM_004958
Target Class:
Kinase
Accession Number:
NM_004958.2
Target Name:
mTOR (FRAP1)
Target Aliases:
FRAP1, RAPT1, MTOR, FRAP, mTOR, FLJ44809, FRAP2, RAFT1
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
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Datasheets

14-770x Datasheet

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