PAK4, active

N-terminal 6His and N-terminal GST-tagged recombinant, human PAK4 amino acids 295-end.

Catalog #: 14-584

$399.00$2,989.00


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Biological Information
Background Information:
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. GenBank NM_005884
Target Class:
Kinase
Accession Number:
Refer to CoA for Accession Number
Target Name:
PAK4
Target Aliases:
PAK4, PAK-4, KIAA1142
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
Usage Disclaimer:
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Datasheets

14-584x Datasheet

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