PDGFRbeta, active

N-terminal 6His-tagged recombinant, human PDGF receptor β, amino acids 557 end.

Catalog #: 14-463

$399.00$2,989.00


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Biological Information
Background Information:
Receptors that are tyrosine protein kinases include those receptors for platelet-derived growth factor (PDGF), insulin, epidermal growth factor (EGF) and certain lymphokines. Receptor tyrosine kinases are cell surface transmembrane proteins responsible for intracellular signal transduction. They are expressed in several cell types and, after activation by growth factor binding, trigger a series of intracellular pathways leading to a wide variety of responses; e.g. differentiation, proliferation, migration and invasion, angiogenesis, survival. Inhibition of PDGFRB (PDGFR1, JTK12, CD140B,Beta platelet-derived growth factor) receptor kinase may be useful in the treatment of several tumors. GenBank J03278
Target Class:
Kinase
Family:
Receptor Typosine Kinase (RTK): Growth Factor Receptor
Accession Number:
NM_002609.3
Target Name:
PDGFRb
Target Aliases:
PDGFRB, PDGFR1, CD140b, PDGFR, JTK12, CD140B, PDGF-R-beta
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
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Datasheets

14-463x Datasheet

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