SRPK1, active

N-terminal GST-tagged recombinant, human SRPK1.

Catalog #: 14-564

$399.00$2,989.00


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Biological Information
Background Information:
Two SR Protein-specific Kinases, SRPK1 and SRPK2, have been shown to phosphorylate specifically the RS motifs of the SR family of splicing factors. Phosphorylation of an SR protein (ASF/SF2) by either SRPk1 or 2 enhanced its interaction with another RS domain-containing protein, and overexpression of either kinase induced specific redistribution of splicing factors in the nucleus. SRPK1 is considered to be a constitutively active kinase predominantly active in testis. Inhibition of SRPK1 may render male germ cell and other tumors insensitive to cisplatin. GenBank NM_003137
Target Class:
Kinase
Accession Number:
NM_003137.3
Target Name:
SRPK1
Target Aliases:
SRPK1, SFRSK1
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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Datasheets

14-564x Datasheet

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