Biological Information | |
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Background Information: | Two SR Protein-specific Kinases, SRPK1 and SRPK2, have been shown to phosphorylate specifically the RS motifs of the SR family of splicing factors. Phosphorylation of an SR protein (ASF/SF2) by either SRPK1 or 2 enhanced its interaction with another RS domain-containing protein, and overexpression of either kinase induced specific redistribution of splicing factors in the nucleus. SRPK2 contains a proline-rich sequence at its NH2 terminus, the capacity to interact with a WW domain protein in vitro. Inhibition of SRPK2 may render male germ cell and other tumors insensitive to cisplatin.
GenBank NM_182691 |
Target Class: | Kinase |
Accession Number: | NM_182691.1; NM_182692.1 |
Target Name: | SRPK2 |
Target Aliases: | SRPK2, FLJ36101, WUGSC:H_RG152G17.1a, SFRSK2, H_RG152G17.1b, H_RG152G17.1a |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
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