STK39, active

N-terminal GST-tagged recombinant, human STK39 full length and N-terminal GST-tagged recombinant, human MO25α full length.

Catalog #: 16-049

$399.00$2,989.00


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Biological Information
Background Information:
STK39 (Serine/Threonine Kinase 39), also known as SPAK (Ste20-related Proline Alanine-rich Kinase), is a serine/threonine protein kinase that is involved in the regulation of ion transport and cell volume in response to changes in osmolarity. STK39 phosphorylates and activates several ion transporters and channels, including the sodium-potassium-chloride cotransporter (NKCC1) and the potassium chloride cotransporter (KCC2), and it has been suggested to play a role in the regulation of blood pressure and salt-sensitive hypertension. Research has also suggested that STK39 may play a role in the regulation of other cellular processes, including cell proliferation, cell cycle progression, and apoptosis. Additionally, STK39 has been implicated in several diseases, including hypertension, diabetes, and cancer, and efforts to develop small-molecule inhibitors of the kinase are underway as potential therapies for these conditions.
Target Class:
Kinase
Accession Number:
NM_013233.1; NM_016289.2
Target Name:
STK39
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
Usage Disclaimer:
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Datasheets

16-049x Datasheet

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