TAK1-TAB1 fusion, active

N-terminal 6His-tagged recombinant, human TAK1 amino acids 1-303, fused to human TAB1 amino acids 437-end.

Catalog #: 14-600

$399.00$2,989.00


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Biological Information
Background Information:
TAK1-TAB1 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. GenBank NM_003188
Target Class:
Kinase
Accession Number:
NM_003188.2; NM_145331.1; NM_145332.1; NM_145333.1
Target Name:
Tak1
Target Aliases:
MAP3K7, TAK1, TGF1a
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
Usage Disclaimer:
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Datasheets

14-600x Datasheet

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