Biological Information | |
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Background Information: | TBK1 protein is involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively.
GenBank NM_013254 |
Target Class: | Kinase |
Accession Number: | NM_013254.2 |
Target Name: | TBK1 |
Target Aliases: | TBK1, T2K, NAK, FLJ11330 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
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