Biological Information | |
---|---|
Background Information: | TTK is a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. |
Target Class: | Kinase |
Accession Number: | NM_003318.3 |
Target Name: | TTK |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 1 year at -70°C |
Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
TTK, active
N-terminal GST-tagged, recombinant, human TTK full length, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose.
Datasheets
15-014x Datasheet
View Document