TTK, active

N-terminal GST-tagged, recombinant, human TTK full length, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose.

Catalog #: 15-014

$399.00$2,989.00


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Biological Information
Background Information:
TTK is a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
Target Class:
Kinase
Accession Number:
NM_003318.3
Target Name:
TTK
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
Usage Disclaimer:
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Datasheets

15-014x Datasheet

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