ULK3, active

N-terminal 6His-tagged recombinant, human full length ULK3.

Catalog #: 14-755

$399.00$2,989.00


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Biological Information
Background Information:
ULK3 (Unc-51 Like Kinase 3) is a Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. It acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). It also positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. ULK3 Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. GenBank XM_044630 (DNA has been codon optimized for insect cell expression)
Target Class:
Kinase
Accession Number:
Refer to CoA for Accession Number
Target Name:
ULK3
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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Datasheets

14-755x Datasheet

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