Wee1, active

10 µg of active Wee1. N-terminal GST-tagged and C-terminal 6His-tagged recombinant, human Wee1 amino acids 214-end.

Catalog #: 14-925

$399.00$2,989.00


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Biological Information
Background Information:
Wee1 is a protein kinase that plays an important role in the regulation of the cell cycle, particularly in the G2 checkpoint. It functions to inhibit the activity of cyclin-dependent kinase 1 (CDK1), a key regulator of the G2/M transition, by phosphorylating it on a specific tyrosine residue. This phosphorylation inactivates CDK1, preventing the cell from entering mitosis until DNA replication and repair processes have been completed. Research has suggested that Wee1 plays a role in several diseases, including cancer and neurodegenerative diseases. In cancer, inhibition of Wee1 has been suggested as a potential therapy to sensitize cancer cells to DNA damage and improve the efficacy of chemotherapy and radiotherapy. Additionally, Wee1 has been implicated in the regulation of neuronal survival and degeneration, making it a potential target for the treatment of neurodegenerative diseases.
Target Class:
Kinase
Accession Number:
NM_003390
Target Name:
WEE1
Target Aliases:
WEE1
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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Datasheets

14-925x Datasheet

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