Quality Control & Stability Testing -

Applications & Products

Bioassays for Potency & Stability Testing in Quality Control/Lot Release

High Reproducibility with a Simple Protocol for over 750 Targets

PathHunter® Bioassays are ideal for determining drug potency and stability using a simple and rapid, mix & read protocol that reflects the drug’s clinical mechanism of action. These validated assays have been optimized for superior bioassay performance to enable a successful regulatory submission package, increasing quality and success of the program.

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View List of Targets

Assay Linearity of PathHunter Bioassays for Stability Testing

Key Features & Highlights

Over 1000 available assays
High reproducibility
Simple protocol with rapid results
Reflective of clinical MOA
Convenient and easy to transfer

Assay Availability

Stable clonal cell line
Frozen, thaw-and-use format (Bioassay Kits)

Linearity and range of the GLP1R PathHunter Bioassay was evaluated by testing with theoretical agonist activities ranging from 50% to 150%. The assay was linear over the range tested indicating suitability of the assay to indicate drug stability.

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Bioassays for Quality Control and Stability Testing During Biopharmaceutical Manufacturing

Target-Specific and Robust Response

IGF1R Assay Specificity

GLP1R Time Course Assay

Target Specific And Robust Assay PathHunter assays provide a target specific response to ligand. IGF1R assay (left panel) using the noted agonists and only observed a response with the IGF1 protein. PathHunter assays are extremely robust assays with a simple protocol. As noted in the GLP1R assay (right panel) at a variety of different time points and observed a robust, stable signal after 15 minutes.

IGF1R Assay Specificity		GLP1R Time Course Assay

Target Specific And Robust Assay PathHunter assays provide a target specific response to ligand. IGF1R assay (left panel) using the noted agonists and only observed a response with the IGF1 protein. PathHunter assays are extremely robust assays with a simple protocol. As noted in the GLP1R assay (right panel) at a variety of different time points and observed a robust, stable signal after 15 minutes.