Scientific Posters

Ubiquitin-mediated degradation of signaling proteins is a primary means of signal regulation in a wide variety of cellular processes including…

Kinase targets have been extensively studied in biochemical assays using purified protein fragments for the kinase and the substrate. However,…

Kinase targets have been extensively studied in biochemical assays using purified protein fragments for the kinase and the substrate. However,…

Neutralizing antibodies (NAbs) to biological drugs may cause loss of therapeutic effi cacy and in some cases, loss of endogenous…

The cAMP detection technologies are widely used in high throughput screening (HTS) for measuring a functional response of a GPCR…

Both multi- and single-pass membrane receptors constitutively exhibit complicated and dynamic membrane receptor trafficking as well as internalization induced by…

Reporter genes are a well-established method used to develop cell-based assays for testing drugs that inhibit or activate targets involved…

Regulation of immune responses is tightly controlled through a balance of co-stimulatory and inhibitory checkpoint receptors, often exploited by many…

Assays that directly detect compound binding inside cells can be of great utility in translating in vitro data to more…

It is well established that ligand binding can protect proteins from thermal denaturation in a cellular milieu; however, the broad…

Compounds that bind to allosteric sites offer many benefits over those which interact orthosterically. These include enhanced specificity, ability to…

Mast cells are principal players in IgE-, and more recently, non-IgE-mediated anaphylactoid reactions or pseudo-allergic Adverse Drug Reactions (ADR). A…