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5-hydroxytryptamine receptor 2B (5HT2B) - HTR2B

Target Class GPCR Family5-Hydroxytryptamine
SpeciesHuman   
Background
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]

Cell Background
HEK 293
Readout
Calcium
Method
Detect calcium mobilization using DiscoverX Calcium No WashPLUS
Agonist/Ligand
5-HT
Agonist Effect (Activation)
potential cardiac valvulopathy; pulmonary hypertension
Antagonist Effect (Inhibition)
possible cardiac effects during embryonic development
Ref.
Bowes et. al. 2012
Cells are plated in a 384-well plate and incubated overnight at 37°C/5% CO2 to allow the cells to attach and grow. Cells are then stimulated with a control agonist. Following stimulation, calcium mobilization is detected using the Calcium No WashPLUS detection kit.
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