Find a Product

5-hydroxytryptamine receptor 2B (5HT2B) - HTR2B

Target Class GPCR Family5-Hydroxytryptamine
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]

Cell Background
HEK 293
Detect calcium mobilization using DiscoverX Calcium No WashPLUS
Agonist Effect (Activation)
potential cardiac valvulopathy; pulmonary hypertension
Antagonist Effect (Inhibition)
possible cardiac effects during embryonic development
Bowes et. al. 2012
Cells are plated in a 384-well plate and incubated overnight at 37°C/5% CO2 to allow the cells to attach and grow. Cells are then stimulated with a control agonist. Following stimulation, calcium mobilization is detected using the Calcium No WashPLUS detection kit.
For other SAFETYscan assays, please click here.

For additional GPCR targets, please click here.

For additional kinase targets, please click here.