Targets / Checkpoint / PD-1
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Programmed cell death protein 1 (PD1)

Target Class
Checkpoint Receptor
Family
T cell receptor (inhibitory)
Official Symbol
PD-1
Species
Human
Accession Number
NM_005018.2
Alias Names
PDCD1; CD279; PD1; SLEB2; hPD-1; hSLE1
Background
PD-1, functioning as an immune checkpoint, plays an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells). A new class of drugs that block PD-1, the PD-1 inhibitors, activate the immune system to attack tumors and are therefore used with varying success to treat some types of cancer.
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Solution Portfolio

Related Group Members: T cell receptor (inhibitory)
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Cell Lines
Assay Measures Background Species Cell Line
Receptor Phosphorylation Jurkat Human 93-1104C19
Receptor Phosphorylation Jurkat Human 93-1106C19
Transcriptional Reporter Jurkat Human 93-1153C19
Dimerization U2OS Human 93-1130C3
Ready to Use Bioassay Kits
Assay Qualified With Assay Measures Background Species Assay Kit
Keytruda® SH2 Recruitment Jurkat Human 93-1104Y19-00117
Keytruda® SH2 Recruitment Jurkat Human 93-1104Y19-00118
LeadHunter Screening & Profiling Services
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan