Angiotensin II receptor, type 1 (AT1)
- Target Class
- GPCR
- Family
- Angiotensin
- Official Symbol
- AGTR1
- Species
- Human
- Accession Number
- NM_000685
- Alias Names
- AG2S; AGTR1A; AGTR1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R; angiotensin II receptor, type 1; angiotensin II type-1 receptor; angiotensin receptor 1; angiotensin receptor 1B; type-1 angiotensin II receptor; type-1B angiotensin II receptor
- Background
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq, Jul 2008]
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Solution Portfolio
Related Family Members:
Angiotensin
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0312C2 |
| Assay Qualified With |
Assay Measures |
Background |
Species |
Assay Kit |
| Angiotensin II |
β-Arrestin |
CHO-K1 |
Human |
93-0312Y2-00125 |
| Angiotensin II |
β-Arrestin |
CHO-K1 |
Human |
93-0312Y2-00126 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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