Chemokine (C-C motif) receptor 3 (CCR3)
- Target Class
- GPCR
- Family
- Chemokine
- Official Symbol
- CCR3
- Species
- Human
- Accession Number
- NM_001837
- Alias Names
- C-C CKR-3; C-C chemokine receptor type 3; CC chemokine receptor 3; CC-CKR-3; CCR-3; CD193; CKR3; CMKBR3; b-chemokine receptor; chemokine (C-C motif) receptor 3; eosinophil CC chemokine receptor 3; eosinophil eotaxin receptor
- Background
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
+ Show More
Solution Portfolio
Related Family Members:
Chemokine
?
DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0629C2 |
|
Chem-1 |
Human |
HTS008C |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
| |
|
|
|
Available |
|
The DiscoveRx Advantage:
Access your Target with Three Signaling Platforms