prostaglandin D2 receptor 2 (PTGDR2)
- Target Class
- GPCR
- Family
- Prostanoid
- Official Symbol
- CRTH2
- Species
- Human
- Accession Number
- AY507142
- Alias Names
- CD294; CRTH2; DL1R; DP2; G protein-coupled receptor 44; G-protein coupled receptor 44; GPR44; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; chemoattractant receptor-homologous molecule expressed on TH2 cells; prostaglandin D2 receptor 2; putative G-protein coupled receptor 44
- Background
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity).
+ Show More
Solution Portfolio
Related Family Members:
Prostanoid
?
DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0291C2 |
| β-Arrestin |
U2OS |
Human |
93-0559C3 |
| cAMP |
CHO-K1 |
Human |
95-0072C2 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
| |
|
|
|
Available |
|
The DiscoveRx Advantage:
Access your Target with Three Signaling Platforms