prostaglandin D2 receptor 2 (PTGDR2)

Target Class
Official Symbol
Accession Number
Alias Names
CD294; CRTH2; DL1R; DP2; G protein-coupled receptor 44; G-protein coupled receptor 44; GPR44; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; chemoattractant receptor-homologous molecule expressed on TH2 cells; prostaglandin D2 receptor 2; putative G-protein coupled receptor 44
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity).
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Solution Portfolio

Related Family Members:


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Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0291C2
β-Arrestin U2OS Human 93-0559C3
cAMP CHO-K1 Human 95-0072C2
Assay Readout Background Species Assay Kit
β-Arrestin CHO-K1 Human 93-0291E2CP2M
β-Arrestin CHO-K1 Human 93-0291E2CP2L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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