CXCR1 -

Targets

Chemokine (C-X-C motif) receptor 1 (CXCR1)

Target Class

GPCR

Family

Chemokine

Official Symbol

CXCR1

Species

Human

Accession Number

NM_000634

Alias Names

C-C; C-C-CKR-1; C-X-C chemokine receptor type 1; CD128; CD181; CDw128a; CKR-1; CMKAR1; CXC-R1; CXCR-1; IL-8 receptor type 1; IL-8R A; IL8R1; IL8RA; IL8RBA; chemokine (C-X-C motif) receptor 1; high affinity interleukin-8 receptor A; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A

Background

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

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Related Family Members:

Chemokine

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family