Chemokine (C-X-C motif) receptor 1 (CXCR1)
- Target Class
- GPCR
- Family
- Chemokine
- Official Symbol
- CXCR1
- Species
- Human
- Accession Number
- NM_000634
- Alias Names
- C-C; C-C-CKR-1; C-X-C chemokine receptor type 1; CD128; CD181; CDw128a; CKR-1; CMKAR1; CXC-R1; CXCR-1; IL-8 receptor type 1; IL-8R A; IL8R1; IL8RA; IL8RBA; chemokine (C-X-C motif) receptor 1; high affinity interleukin-8 receptor A; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A
- Background
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
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Solution Portfolio
Related Family Members:
Chemokine
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
Assay Readout |
Background |
Species |
Cell Line |
β-Arrestin |
U2OS |
Human |
93-0226C3 |
Internalization |
U2OS |
Human |
93-0659C3 |
cAMP |
CHO-K1 |
Human |
95-0073C2 |
KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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